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FIBIOS

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Bioactive film acting as an active principle reservoir for the integration of implants and bone regeneration.

Integrating a BMP (bone morphogenetic protein) solution that stimulates bone regeneration, this natural polymer-based film is used to facilitate implant consolidation. By reinforcing the retention power of the BMP at the surface of the implant, the LMGP team successfully controlled the quantity used of this costly protein, and ensured its delivery and bioactivity maintenance over a period of several days.

» Description and functionalities

Film of micrometric thickness made up of natural polymers, acting as a true active principle reservoir.

» Technology

Film created by a simple charged polymers self-assembly technique, then chemically reticulated to reinforce its mechanical stability.

» Performances

- Modular protein quantity in a wide range.
- Localized, controlled delivery on the material’s surface.
- Film deposited on the materials currently used in clinics (commercial grade Ti, TA6V alloy).
- The technology is compatible with the ISO 10993 standard with reference to the biocompatibility of medical equipment.

» Laboratory

Laboratory of Materials and Physics Engineering (LMGP) - Réf. 081012_PICART_FIBIOS _ 26072011

» Target

Sites of bone lesions or the integration of implants

» Application area

• Orthopedic and rachis surgery
• Maxillo-facial surgery
• Dental surgery
• Protein therapy (anti-inflammatory, anti-bacterial)
• Biomaterials

» Market

The competing technologies use large quantities of protein and are only applicable – at least for the time being – to a collagen sponge. Now, since the protein is not strongly secured by the collagen, there is a strong rejection rate, which occurs rapidly (a few hours). This may lead to adverse effects, because the BMPs have a very high osteogenic potential.
Within this context, our technology allows for localized, controlled delivery of the factor. The recovery proposed allows for the maintenance of the bioactivity and the stability of the protein following sterilization and several months in storage.

» Transfert offer

Seeking industrialists for licensing agreements or collaboration developments.

Interview

The longevity of orthopedic and dental prostheses is still low. The main problem encountered is the integration of the implant. In the short term, it is modulated by the inflammatory reaction and a risk of infection. In the longer term, it depends on the stability of the implant within the tissue and its capacity to resist biological fluids and mechanical constraints.

Thus, the "bioactive" character conferred on these implants allows for the reduction of rejection rates and recovery time and post-operative after-effects.