DIAGIR: the 1st direct diagnostic and prognostic ELISA test for insulin resistance and type 2 diabetes

In the view of numerous studies, early treatment for insulin re-sistance greatly reduces the progress of the disease towards diabe-tes. Thus it is necessary to be able to diagnose insulin resistance as early as possible and before diabetes appears. To date diagnosis is solely based on the determination of glycemia, together or not with insulinemia. These tests, which are tedious if performed under the best conditions (2 hours OGTT), do not directly measure the sensi-tivity of cells to insulin. To deal with this problem, Serge Bottari has developed a new blood test capable of determining the plasma concentration of IRAP, a protein invcolved in the translocation of the glucose transporter GLUT4to the plasma membrane which allows glucose uptake by the cells which are normally sensitive to insulin.

IN OVO ONCOLOGY TESTS: A COMPETITIVE SOLUTION FOR REDUCING PRE-CLINICAL TESTS

The innocuity of candidate molecules, angiogenesis and tumor growth are tested on bird embryos before any pre-clinical tests. These in ovo tests contribute to the reduction in animal experiments and make it possible to anticipate the effects in mammals. 10 times more tests can be performed with a small amount of molecules per test, in a shorter period of time, providing a considerable asset in screening.

A new peri-operative vision of cartilage

The SONARTHRO system is based on a miniaturized, robotized ultrasound probe which can be used peri-operatively without added invasivity. It offers an incomparable echographic image quality, better than that of MRI. Combined with a 3D localization system, its performance makes it a precious display instrument for arthroscopic surgery (cartilage repair, etc.). It also enables medicinal or surgical treatments to be validated.

A new molecule targeting metastase

Laurence Lafanechère and her team have developed a cellular test to select, using a high throughput screening (30,000 molecules), agents targeting the regulators of the cytoskeleton. They have identified a selective inhibitor of the LIM Kinase, an enzyme inplicated in metastasic cells motility. The have proven the toxicity of this molecule on different cancerous lines, including those having developed resistance mechanisms to treatments used in chemotherapy, and have shown its therapeutic effectiveness in pre-clinical regulatory conditions.

Functional in vitro tests to characterise the repair activity of the DNA in biological samples

In response to treatment for cancer or genotoxic stress, such as UV radiation or pollutants, our cells trigger DNA repair systems to ensure their survival. LXRepair tests measure the repair capacities of our cells. LXRepair 1.0 is an innovative, reliable tool aimed at applications both in research (toxicology, biomarkers) and medical diagnostics in order to optimise therapeutic conduct (companion test). Contact : [email protected]

Bioactive film acting as an active principle reservoir for the integration of implants and bone regeneration.

Integrating a BMP (bone morphogenetic protein) solution that stimulates bone regeneration, this natural polymer-based film is used to facilitate implant consolidation. By reinforcing the retention power of the BMP at the surface of the implant, the LMGP team successfully controlled the quantity used of this costly protein, and ensured its delivery and bioactivity maintenance over a period of several days.

Development and production of emerging radioisotopes for medical applications.

Thanks to its exceptionally intense flow of neutrons, the Institut Laue-Langevin (ILL) is capable of producing high-quality innovative radioisotopes that are particularly adapted to the current demands of nuclear medicine. When coupled with selective biological vectors, such as peptides or antibodies, these radioisotopes specifically target certain cells (such as cancerous cells), thus reducing side effects while increasing the treatment's effectiveness.

TACTILE ALERT: A SENSORY DEVICE FOR PREVENTION OF ULCERS BY THE PATIENT

The device developed by Yohan Payan and his fellow researchers allows a patient with a motor handicap to receive a signal suggesting a change of posture to relieve areas of tissue suffering too much pressure. This new concept places the patient at the centre of the perception-action loop.

RELIABLE RESPIRATORY SIGNALS FOR A SAFE STRATEGIC CLINICAL DECISION

In the context of a withdrawal decision for a patient in clinical difficulty, the ORGAR system developed by Pierre-Yves Guméry, researcher, and Laurent Heyer, resuscitator, will provide doctors with fundamental information based on observing the proper coordination of muscle activity in the whole respiratory system.

A molecular optical marker for the eye of the surgeon

Thanks to infrared imaging of a tumour zone, the molecule-probe device developed by Jean-Luc Coll will enable the surgeon to perform a precise excision and thus avoid surgery which would be incapacitating for the patient.

Local Cooperative Unified Segmentation

Automated segmentation software of the different components of the brain on an RMI 3D image.

Simulatorse: Mecatronic infant torso simulator used for learning respiratory physiotherapeutic manipulations

The simulatorse reacts like a real newborn in the event of an inappropriate manipulation. It reproduces breathing, measures the pertinent parameters of the therapist's manipulations, and simulates respiratory blockages. Data processing software also allows users to visualize the pressure points applied by the physiotherapist.

Electrostatic microsystem for the recovery of vibration energy to power sensors

Particularly suited to the automotive industry, this energy conversion system, taking up barely 1 sq. cm. provides power to numerous sensors, in particular, to those positioned in confined spaces. Its effectiveness remains today unequalled, since it operates on a wide frequency band from only 30 Hz up to 120 Hz.

Ecological polymers suitable for the manufacture of flash memories

Developed to be able to incorporate patterns less than 10 nanometres apart, these resins will make it possible to reduce the size of future micro-electronics objects even more, while increasing the density of the information they contain.

LIQUID METAL THERMAL SPREADER: A 2-in-1 cooling system for electronic power components

More compact and more effective, this spreader cools electronic components by circulating liquid metal directly underneath them. The choice of metal and the configuration of the circuit solves both the problem of solidification of the liquid and the remoteness of the MHD pump, giving this innovative spreader a probable capacity for the evacuation of heat flow densities up to a kW per square centimetre of silicon.

SAMSON: Adaptive system for the modelisation and simulation of nanoscopic objects

Samson is a software platform used in the modeling and simulation of natural or artificial complex nanosystems.

SMART VIDEO OBJECT STUDIO

Track, cut out and exploit objects in videos. An authoring tool for extracting objects all along a video. The easiest way to enrich videos with interaction and special effects. - User friendly - Speed up and ease tedious work

A VERIFICATION SOLUTION FOR COMPLEX SOC'S

3D contactless interactive multimedia tablet

Magic Pad is a technological demonstrator with revolutionary large-area image capture functionalities, 3D navigation of multimedia content and recognition of hand gestures on printed organic electronics. This illustrates the man/machine interface possibilities, by virtue of the integration of optical sensors that measure position, distance and hand movements above the surface.

Built-in Self-test for SIGMA-DELTA ADCs

Save on your analog test costs of Sigma-Delta ADCs with a purely digital built-in self-test technique.

Real-time geovisualization

Proland allows for interactive exploring of geographic environments using real-time 3D visualization and realistic multi-resolution rendering.

Waterproof peripheral used to control a virtual hand in virtual worlds

HandNavigator allows users to control between 1 and 10 degrees of freedom – even more – and to remotely handle objects with a high degree of precision.

Make your digital simulations more profitable

Better achieve a set of digital simulations in order to obtain the optimum points of your systems more rapidly Analyse the results using metamodels, visualize, optimize, carry out statistical studies, …

RFID system for label identification

- «Specific» individual identification - «Production line» identification

AudioActivity: for active music listening on .wav files

As a result of pre-treatment with audio-digital tattooing “Audioactivity” enables any listener, private or professional, to remix a piece of music on a .wav file as they wish, while retaining the original bandwidth and sound quality.

MASsive Successive Approximation Register (MASSAR)

The power consumption for an array of high resolution and fast Analog to Digital converter is under control.

Environmentally high quality Li-ion-Paper Battery

The PAPEL battery is flexible, ecological and economic. It could meet the production requirements of small stationary and roaming units up to larger scale products such as electric vehicles and renewable energy power stations. Polymer electrodes are replaced by paper electrodes, toxic solvent is removed and the fluorinated binder is replaced by cellulose fibers and microfibrils. As a result of an aqueous filtration procedure and the use of materials of plant origin, the majority of the toxic and inactive components are removed, thus reducing cost and recycling problems.

High output flexible solar inverter

With a conversion rate in the order of 15%, EPISOL is the first solar system with low cost generation potential, compatible with the market for integrated photovoltaic construction. Unlike the current cells the EPISOL structure incorporates a thin layer of silicon on a flexible support. This is carefully built onto a conducting ceramic layer, which itself is placed on a supple metal layer. The latter can thus exercise the function of an electrode, and therefore simplify the system. The architecture obtained, both simple and able to be formed, makes it possible to combine the flexibility of the thin layers with the high outputs of traditional cells.

ALPE: Powerful, dense li-ion accumulators. Value-added materials: an opportunity for electric vehicles and powertools?

At the CEA-LCE, specialized in Li-ion accumulators, the group led by Sébastien Patoux develops synthetic materials and procedures for electrode materials of Li-ion batteries.

Integrated solutions for managing lithium-ion battery packs in mobile and stationary applications

Advanced EMS is a new battery that offers twice the shelf-life of other batteries and a guarantee of autonomy, two of the essential elements in the emerging electric mobility.

System of multi-beam spraying for implantation and thin layer: Multi Beam Sputtering

The challenge met by Pascal Sortais is to produce a wide beam of very high intensity and low energy to treat surfaces of varied, diverse shapes and sizes at low cost. A single wide beam source of ions is replaced by a multitude of small very compact and very reliable sources, which make it possible to pick up an evaporation target or a substrate at any angle.

Innovative design of cold crucible with high energy efficiency

Designed to be produced in steel plate, the ECCU straight-sided crucible achieves an energy yield of 50% as against 35% for classic straight-sided crucibles. Using an innovative technological design (reduced thickness of the sectors and externalising of the insulating material cooling system), the energy saving produced results in an improved power to raise the temperature and an improved capability beyond the melting point. These crucibles are optimised for use with highly reactive titanium alloys (Ti, TiAl).

A NEW MULTIFILAMENT 3-IN-1 MATERIAL AND ITS PRODUCTION PROCESS

Thanks to his new process, Jean-Jacques Blandin unlocks the secret of assembling a metallic glass and a metallic alloy. The result is a previously unheard-of combination of 3 properties: conductivity, strength and lightness.

A DISRUPTIVE INNOVATION FOR DURABLE MANAGEMENT OF CONCRETE INFRASTRUCTURES

To detect at a very early stage and pinpoint the point of damage of a concrete structure, Eric Larose has developed a monitoring technique using ultrasound combined with signal-processing software, the latter developed by Vincent Rossetto. An innovation that will become essential for civil engineering.

MULTI-BEAM IMPLANTER

Producing a wide beam at a very high density and low energy to treat surfaces of different shapes and sizes at a lower cost is the challenge tackled by Pascal Sortais. A unique source of wide-beam ions is replaced by a multitude of small sources, which are very compact and very reliable, allowing users to solicit an evaporation target or a substrate at any given angle.

Unprecedented technology for NON INTRUSIVE monitoring of ferromagnetic structures

- Real-time contactless monitoring - Post-incident measurement expertise - Quality or certification measuring during the production phase

Imagery for the Instrumentation of Nature and the Environment, adapted to high-risk areas.

Whatever the size and spate of weather conditions, the IMAGINE video and image analytical software provides real-time hydrometric measurements and images of rivers. Remotely installed and protected from water levels, IMAGINE continues to guage rivers when classic sensors can no longer do so.

Automatic spectral description

Automatically get a detailed spectral description of the signal you are monitoring.

Calculations on a heterogeneous platform

Set up and predict your own weather forecasts by associating the powerful calculating capabilities of your work stations and personal computers.